Posts Tagged ‘course’

A report on the 7th European Short Course on Laboratory Animal Science in Strasbourg, organized by Charles River

Friday, February 14th, 2014
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A report on the 7th European Short Course on Laboratory Animal Science in Strasbourg, organized by Charles River

A report on the 7th European Short Course on Laboratory Animal Science in Strasbourg, organized by Charles River

The 7th European Short Course on Laboratory Animal Science, organized by Charles River, just closed in Strasbourg, France, after three days of interesting presentations and discussions at the intersection between animal welfare, animal experimentation, current guidelines and legislation, biomedical research from academia and industry and society perception on these topics. The Organizers should be praised for the selection and variety of topics, as well as for the smooth and pleasant running of the entire course, which included an enjoyable visit to an old typical cellar from the Alsace region along with a wine-testing Gala dinner.

Several ISTT members participated in this event, including organizers (Cyril Desvignes, Jean Cozzi), members of the steering committee (Johannes Wilbertz), invited speakers (Belén Pintado, Yann Herault, Ignacio Anegon, Lluís Montoliu), and participants (Marcello Raspa, Ferenc Erdelyi, Gabor Szabo,…) among other.

During this course, the recent EU Directive 2010/63 on the protection of animals used in research and its implication on the use of animals in biomedical research and policies throughout Europe was discussed, from different angles, by Magda Chlebus, Gill Fleetwood, Thierry Decelle, Patri Vergara and Belén Pintado. Topics covered included the new training courses and competencies to work with experimentation animals in Europe, the animal-welfare bodies and the current understanding of the 3R’s paradigm. Javier Guillén compared, side by side, the new EU Directive with the current Guide in the US and highlighted their many coincidences, suggesting that a combined use of both documents would be ideal for the adoption of successful animal care and use programs. Jan-Bas Prins, current president of FELASA, presented his view of the field of laboratory animal sciences, before the implementation of this new EU Directive, as an opportunity and a positive challenge to interface and exchange knowledge with many other players involved.

Health monitoring programs, rodent microbiologic surveillance, methods employed to detect all these pathogens robustly in laboratory animal facilities and the updated recommendations from FELASA, recently published in Laboratory Animals, were presented by William Shek, Guy Mulder, Stéphanie Durand and Axel Kornerup Hansen. Operational and technical aspects of animal facilities were discussed by Alberto Gobbi and Peter Dockx, whereas the issues related with occupational health and safety program evaluations were presented by Jann Hau.

Examples of the use of rodent animal models in biomedical research, in academia, by James Di Santo and Andrea Bertotti, as well as in the industry, by Joyce L. Young, were discussed. The importance of genetic quality in mouse research as well as the complexity of mouse genome and the impact of the genetic background on phenotypes was presented by Charles Miller and Lluís Montoliu, respectively. The procedures conducted at the International Mouse Phenotyping Consortium (IMPC) as well as the challenges they encountered during the deployment of this impressively large enterprise were presented and discussed by Sara Wells and, by the local representative, Yann Herault, Director of the French Mouse Clinic, ICS, in Strasbourg, who delivered the closing talk.

The newest technologies in stem cell biology and animal transgenesis were also present at this 7th Short Course. Hongkui Deng summarized the most innovative approach he devised to prepare induced-pluripotent cells from somatic cells, using a cocktail of four chemicals, four molecules that mimicked the induction signals described by Shinya Yamanaka. The new logics for the production of targeted genetic modifications, using editing or engineered nucleases (Meganuclease, ZFNs, TALENs, CRISPRs) in mice and rats was presented by Ralf Kuehn and Ignacio Anegon, respectively.

The choice of rodent anaestesia protocols was discussed by Aurelie Thomas, whereas the various methods for euthanasia in rodents were presented by Huw Golledge. On the last day, Aurora Bronstad summarized the work done at the AALAS-FELASA joint working group on harm-benefit analysis, whereas Katrina Gore highlighted the need for more robust analytical procedures in research protocols involving animal experimentation, in order to optimize the rate of success of pre-clinical drugs.

In summary, the 7th Edition of this biennial Charles River Short Course on Laboratory Animal Science in Europe, attended by some 120 participants, was an excellent opportunity to update information related to animal welfare, EU legislation and transposition difficulties in various countries, newest technologies, mouse genomics and genetics, large mouse consortia and numerous important topics that are relevant for animal facility managers, researchers, veterinarians and anyone else interested in the best use of animals in experiments, according to current laws and recommendations.

7th European Short Course on Laboratory Animal Science in Strasbourg (France), on 12-14 February 2014

Wednesday, January 8th, 2014
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7th European Short Course on Laboratory Animal Science in Strasbourg (France), on 12-14 February 2014

7th European Short Course on Laboratory Animal Science in Strasbourg (France), on 12-14 February 2014

Charles River announces the 7th European Short Course on Laboratory Animal Science in Strasbourg, France, on 12-14 February 2014. This Short Course is designed to inform the biomedical research community of current trends and technological advances in the field of laboratory animal science through lectures from international guest speakers and members of Charles River’s professional Staff. A number of ISTT members are included among the invited teachers at this course.

The full list of speakers includes: Magda Chlebus (European Federation of Pharmaceutical Industries and Associations, Belgium), Gill Fleetwood (GlaxoSmithKline, United Kingdom), Sara Wells (Mary Lyon Centre, United Kingdom), Hongkui Deng (Peking University, College of Life Science, China), Javier Guillen (AAALAC International, Spain), Thierry Decelle (Sanofi Pasteur, France), William R. Shek (Research Animal Diagnostic Services, Charles River, USA), Guy Mulder (Senior Director Veterinary and Professional Services, Charles River, USA), Patri Vergara (University Autonomous of Barcelona, Spain), Belen Pintado (Transgenic Unit CNB-CBMSO, CSIC, Spain), Stéphanie Durand (Research Animal Diagnostic Services, Charles River, USA), Axel Kornerup Hansen (Faculty of Health and Medical Sciences, University of Copenhagen, Denmark), Lluis Montoliu (National Centre for Biotechnology, CNB-CSIC, Spain), Ralph Kuehn (Institute of Developmental Genetics, Helmholtz Center Munich, Germany), Ignacio Anegon (INSERM UMR 1064 -Center for Research in Transplantation and Immunology and Platform Transgenic Rats ImmunoPhenomic Nantes, France), Jan-Bas Prins (Leiden University Medical Centre, The Netherlands), Joyce L. Young (Crescendo Biologics Ltd, United Kingdom), Charles Miller (The Jackson Laboratory, USA), James Di Santo (Innate Immunity Unit, Inserm U668, Institut Pasteur, France), Andrea Bertotti (University of Torino School of Medicine, Institute for Cancer Research and Treatment, Italy), Aurelie Thomas (University of Newcastle – Comparative Biology Centre – Medical School, United Kingdom), Huw Golledge (Centre for Behaviour and Evolution, Institute of Neuroscience, Newcastle University, United Kingdom), Alberto Gobbi (Department of Experimental Oncology, European Institute of Oncology and COGENTECH S.C.A.R.L., Italy), Peter Dockx (Van Looy Group, Belgium), Aurora BrØnstad (University of Bergen, Norway), Jann Hau (University and University Hospitals of Copenhagen, Denmark), Katrina Gore (Pfizer Neusentis, United Kingdom), Yann Herault (Institut Clinique de la Souris-ICS, France).

All attendees receive a certificate of attendance for their course hours which they may submit for Continuing Professional Education Credits.

Instructions and registration details are provided in this EU Short Course brochure.

One day meeting in London on Conditional Transgenic Techniques: Principles & Best Practice

Tuesday, July 24th, 2012
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One day meeting in London on Conditional Transgenic Techniques: Principles & Best Practice

One day meeting in London on Conditional Transgenic Techniques: Principles & Best Practice

Registration is now open for a new transgenic training event on “Conditional Transgenic Techniques: Principles & Best Practice“, organized by the RSPCA, Wellcome Trust Sanger Institute, the Leeds Institute of Molecular Medicine, the Mary Lyon Centre from MRC in Harwell, and the National Institute for Medical Research from MRC in London.

This is a one day meeting on current best practice in the production of genetically altered mice, using conditional transgenic techniques. Topics will include:
* the technology of inducible and conditional systems
* examples of their use
* recombinases: whats available, limitations & how to test efficacy
* conditional allele resources
* breeding schemes

The meeting is being held in central London on Thursday 4th October 2012, and is limited to 100 places allocated on a first come first served basis. Registration (including lunch) will cost £60, so for more information or to book a place and get a registration form email GA@rspca.org.uk putting “conditional workshop” in the title field.

NIH Course: TRAC 12:Transgenic Technology: Methods and Application, Jan 9-13, 2012

Saturday, December 3rd, 2011
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TRAC 12:Transgenic Technology: Methods and Application
TRAC 12:Transgenic Technology: Methods and Application

The TRAC 12:Transgenic Technology: Methods and Application Course is a four-day Biotechnology Training Courses at the National Institutes of Health that will be held on January 9-12, 2012. According to its web site: “This lecture/laboratory demonstration course is intended for those who wish to develop a strong background in transgenic techniques and applications. The two dominant approaches to transgenic technology will be emphasized, namely classic transgenic production by pronuclear microinjection and knockout transgenic production(gene targeting) by blastocyst injection with embryonic stem (ES) cells. The comprehensive coverage will address supporting technology (e.g. cryopreservation, rederivation, Intracytoplasmic Sperm Injection(ICSI), In Vitro Fertilization (IVF) , animal husbandry and surgery) as well as the molecular biology/recombinant DNA aspects of transgenesis.”

The TRAC12 Course will cover the following topics: Transgenic Technology overview  (Embryonic Development,  Optimizing Constructs for in vivo Expression,  Preparation of Females for Embryo Collection, Pronuclear Microinjection,  Generation of Pseudopregnant Females,  Implantantation in Foster Mothers,  Identification of Transgenic Progeny,  Optimization of Breeding Population from Founders);  Lentiviral and BAC transgenisis;  Gene Targeted Transgenisis (Isolation and Maintenance of Totipotent embryonic Stem Cells for the Generation of Chimeric Mice; Homologous Recombination in ES Cells; Construct Design, Transfection, Selection; Generation of Gene Knockout Mice using Targeted ES Cells; Blastocyst Injection; Optimizing Germ-line Chimeras);  Alternative Methods for Generating Targeted Mice: 8_cell Embryo Injection and ES Cell Aggregation;  transgenic phenotype analysis;  Transgenic Animal Model Supporting Techniques (Cryopreservation and rederivation;  ICSI and IVF; Transgenic Model Future Prospects); Transgenic Model FuFuture Prospects; Sampling Project Question and Answer; Live and Video Demonstrations and hands on work (e.g. microinjection; Superovulation; Embryo Harvest and Transfer).

Applications to attend this TRAC 12 course can be submitted through this web site.

WTSI Course on Genetic Manipulation of ES cells

Tuesday, June 14th, 2011
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WTSI Course on Genetic Manipulation of ES cells, 31 October-13 November 2011

WTSI Course on Genetic Manipulation of ES cells, 31 October-13 November 2011

The Wellcome Trust Sanger Institute (WTSI), at Hinxton (UK), organizes a course on “Genetic Manipulation of ES cells that will be held on 31 October-13 November 2011. This Wellcome Trust Advanced Course will provide a comprehensive overview and practical laboratory experience of the genetic manipulation of mouse ES cells for a broad range of applications. The course instructors include Course instructors Prof. Francis Stewart, ISTT Honorary Member, from Dresden University of Technology, Germany and Dr William Skarnes, Dr Pentao Liu, and Dr Barry Rosen, from WTSI, UK.

Guest speakers include Toni Cathomen (Hannover Medical School, Germany), Austin Smith (Wellcome Trust Centre for Stem Cell Research, UK), Roger Pedersen (University of Cambridge, UK), Allan Bradley (Wellcome Trust Sanger Institute, UK), Meinrad Busslinger (Research Institute of Molecular Pathology, Austria) and Timm Schroeder (Helmholtz Zentrum München, Germany). Application deadline: 8 July 2011.

A brochure for this course can be downloaded from here.

Course on “Genetics of Laboratory Rodents”, Institut Pasteur de Montevideo, Uruguay, December 5-14, 2011

Saturday, June 4th, 2011
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Course on "Genetics of Laboratory Rodents", Institut Pasteur de Montevideo, Uruguay, December 5-14, 2011

Course on "Genetics of Laboratory Rodents", Institut Pasteur de Montevideo, Uruguay, December 5-14, 2011

The International Society for Transgenic Technologies (ISTT) is pleased to announce the co-sponsorship of the second edition of the International Course on “Genetics of Laboratory Rodents“, to be held at the Institut Pasteur de Montevideo (IPMONT), Uruguay, on 5-14 December 2011. This course is organized by Martina Crispo (IPMONT, ISTT member) and co-organized by Jean Jacques Panthier (Inst. Pasteur Paris). Following a most successful first edition in 2008, the aim of this course is to offer a training opportunity to South American research scientists and veterinarians in charge of laboratory animal facilities, in the most prominent areas of mammalian genetics (mostly mouse). This course offers an opportunity to receive an intensive training and get in touch with scientist of the region working in the same fields of interest.

The invited speakers at this international 2011 course on “Genetics of Laboratory Rodents” include the following experts in the field:

  • Jean Jacques Panthier (Institut Pasteur de Paris, France)
  • Xavier Montagutelli (Institut Pasteur de Paris, France)
  • Jean Louis Guénet (Institut Pasteur de Paris, France)
  • Jean Jaubert (Institut Pasteur de Paris, France) – ISTT  member
  • Michel Cohen Tannoudji (Institut Pasteur de Paris, France)
  • Ignacio Anegón (Institut de Transplantation-Urologie-Néphrologie,France) – ISTT member
  • Marcelo Rubinstein (Facultad de Ciencias Exactas y Naturales, UBA, Argentina)
  • Andreia Salgado (CEMIB, UNICAMP, Brazil)
  • Fernando Benavides (MD Anderson Cancer Center, Texas, USA) – ISTT member
  • Mariela Bollati (Institut Pasteur de Montevideo)
  • Martina Crispo (Institut Pasteur de Montevideo) – ISTT member

Interested participants should sent their applications by email to: curso-genetica-raton@pasteur.edu.uy by September 25, 2011, and include their CV, letter of motivation and letter of support of their advisors, all in PDF format. Two seats are reserved for qualifying ISTT members. There is no registration fee for this course. The 2011 International Course on “Genetics of Laboratory Rodents” is generously sponsored by CABBIO, AMSUD PASTEUR, Institut Pasteur de Montevideo, ISTT and  Ambassade de France en Uruguay.

Course on Managing Mouse Colonies: Best Practices, Genetics, Breeding and Welfare

Tuesday, February 22nd, 2011
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Course on Managing Mouse Colonies: Best Practices, Genetics, Breeding and Welfare, June 13-16, 2011, WTCC, Hinxton, UK

Course on Managing Mouse Colonies: Best Practices, Genetics, Breeding and Welfare, June 13-16, 2011, WTCC, Hinxton, UK

The International Society for Transgenic Technologies (ISTT) is happy to support the second edition of the Course on Managing Mouse Colonies: Best Practices, Genetics, Breeding and Welfare, organized as a collaboration between MRC Harwell, the Leeds Institute of Molecular Medicine and the Wellcome Trust Sanger Institute, and aiming to introduce experienced technicians and scientific staff involved with the management of genetically-modified mouse colonies. The Course will be held at the Wellcome Trust Conference Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, on June 13-16, 2011, and  is organized by James Bussell (WTSI), ISTT Member; Neil Dear (LIMM) and Sara Wells (MRC). Application deadline is April 1, 2011

The course looks at historical and current best practice in the maintenance of genetically-modified mouse colonies for scientific research and the differing disciplines involved in production phenotyping and archiving. All of these are presented with particular attention to the 3Rs and animal welfare. Confirmed tutors attending this course include:

James Bussell, Wellcome Trust Sanger Institute, UK
Michael Cheeseman, Medical Research Council, Harwell, UK
Neil Dear, Leeds Institute of Molecular Medicine, UK
Adrian Deeny, University College London, UK
Martin Fray, Medical Research Council, Harwell, UK
Ian Jackson, Medical Research Council Human Genetics Unit, UK
Sarah Johnson, Medical Research Council,  NIMR, UK
Natasha Karp, Wellcome Trust Sanger Institute, UK
Raffaele Matteoni, European Mouse Mutant Archive DataBase, Italy
Karen Steel, Wellcome Trust Sanger Institute, UK
Sara Wells, Medical Research Council, Harwell, UK
Jacqui White, Wellcome Trust Sanger Institute, UK
Ben Woodman, Leeds Institute of Molecular Medicine, UK

The Organizers of this 2nd Edition of the Course hope again to attract a very diverse group of participants from a Scientific, Veterinary and Animal Technology background. This in itself provided a great dynamic when discussing the various routines and concepts involved with genetically-modified mouse production, maintenance, utilisation and cryopreservation. Underpinning this are the good practices associated with animal welfare and the 3R’s.


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