The International Society for Transgenic Technologies (ISTT) will be participating and/or co-sponsoring numerous events during the month of June 2013. At first, on June 7, 2013, our ISTT colleagues from Nantes (France), Ignacio Anegon and Séverine Ménoret, experts in the generation of transgenic rats, will be holding their 2013 Nantes Transgenic meeting on “Technical advances in the generation of transgenic animals and in their applications“. Next, on June 10-13, 2013, in Barcelona (Spain), the 12th FELASA-SECAL congress will take place, where the ISTT will be participating in two ways. First, the ISTT will co-sponsor the satellite workshop on Mouse Sperm Cryopreservation, to be held within the 2013 FELASA meeting, on 10 June 2013, Barcelona, Spain, and organized by ISTT members Jorge Sztein (NIH, USA) and Jesús Martínez-Palacio (CIEMAT, Madrid, Spain). Second, the ISTT will be participating as exhibitor and will attend the 2013 FELASA meeting. The ISTT will have a booth in Barcelona (#230), manned by the ISTT administrative assistant, Alison Cameron, and where all ISTT members (and non-ISTT members) are welcome to visiting us. Finally, immediately next, our ISTT colleagues from The Netherlands, Marian Van Roon (VU, Amsterdam) and Sjef Verbeek (LUMC, Leiden), have organized their 2013 Workshop on Innovative Mouse Models (IMM2013). This 7th Workshop on Innovative Mouse Models will be held on 13-14 June 2013, at the Leiden University Medical Center, LUMC, Leiden, The Netherlands, and the ISTT will be co-sponsoring also this event. ISTT members will be entitled to reduced registrations at all these events, proudly co-sponsored by the ISTT.
Archive for the ‘transgenic research’ Category
The TT2013 meeting report, written by Douglas Strathdee (Beatson Institute for Cancer Research, Glasgow, Scotland, UK) and C. Bruce A. Whitelaw (Division of Developmental Biology, The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Roslin, Midlothian, Scotland, UK) has just been published, online, at the Transgenic Research journal web site. This review, entitled ‘TT2013 meeting report: the Transgenic Technology meeting visits Asia for the first time‘ nicely summarizes the talks and activities held during the recent 11th Transgenic Technology meeting, held in Guangzhou (China), on February 25-27, 2013, along with the subsequent hands-on workshop that was organized, on February 28-March 2, 2013. Douglas and Bruce, together with Peter Hohenstein (Division of Developmental Biology, The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Roslin, Midlothian, Scotland, UK) are the Organizers of the next 12th Transgenic Technology meeting, TT2014, which will be held in Edinburgh (Scotland, UK) on October 6-8, 2014.
Researchers at the Institute of Animal Reproduction in Uruguay (IRAUy), led by Alejo Menchaca (ISTT Member), in collaboration with members of the Transgenic and Experimental Animal Unit (UATE) of the Institut Pasteur de Montevideo, led by Martina Crispo (ISTT Member) and Ignacio Anegon‘s laboratory (ISTT Member), of the Transgenic Rats common facility, ITERT, INSERM, Nantes, France, working in Europe but born in Uruguay, have announced the generation of several green transgenic sheep made with lentiviruses carrying a GFP reporter transgene. These green animals represent the first transgenic sheep produced in Uruguay, and in SouthAmerica. According to the press release and the authors of this biotechnological project, up to nine transgenic sheep were generated last year, 6 months ago, at the IRAUy, after 2 years of work.
This proof-of-concept experiment demonstrates the technological skills and capacity of these teams and institutions in Uruguay, who have been able to produce these first transgenic lambs, and hence, they must be praised by their achievement. In the future, additional genetically modified livestock will be created, aiming to produce recombinant proteins of biomedical or industrial interest in the milk of these transgenic animals, following similar experiments already carried out in other countries. The International Society for Transgenic Technologies (ISTT) is proud to count among its members these three excellent researchers and wishes to congratulate them for their success in their experiments.
The most immediate precedents for genetically modified livestock in SouthAmerica include transgenic goats generated in 2009 by the team of Vicente Freitas (ISTT Member) at the State University of Ceará, Fortaleza (Brazil), expressing hG-CSF in their milk, and several transgenic cows generated by a biotech firm, Biosidus, and by INTA, in Argentina, in 2008 and 2011, respectively, producing therapeutical proteins in their milk.
“Yale scientist Francis Hugh (Frank) Ruddle, a pioneer in genetic engineering and the study of developmental genetics, died March 10 in New Haven. He was 83 years old“. This is how a text in memoriam of Frank Ruddle, who passed away last Sunday, begins, at the Yale University web site. Frank Ruddle was Professor Emeritus at the Department of Molecular and Developmental, Yale University. In collaboration with Jon W. Gordon, from the Mount Sinai School of Medicine in New York, at the time one of his post-docs, Frank Ruddle devised and succeeded in creating the first transgenic mice, the first animals genetically modified after microinjecting a plasmid DNA into the pronuclei of fertilized mouse eggs. These seminal papers were published in 1980 and 1981. In order to remember Frank Ruddle’s pioneer contributions to the field of transgenic technologies, to highlight the relevance of their findings among our youngest colleagues, and to adequately assess, in perspective, their fantastic achievements, made more than 30 years ago (or only 30 years ago, depending how you would like to see the case) I am citing here the full abstracts, as they appear published in their respective journals, PNAS (in 1980) and Science (in 1981).
Genetic transformation of mouse embryos by microinjection of purified DNA.
Gordon JW, Scangos GA, Plotkin DJ, Barbosa JA, Ruddle FH.
Proc Natl Acad Sci U S A. 1980 Dec;77(12):7380-4.
ABSTRACT: “A recombinant plasmid composed of segments of herpes simplex virus and simian virus 40 viral DNA inserted into the bacterial plasmid pBR322 was microinjected into pronuclei of fertilized mouse oocytes. The embryos were implanted in the oviducts of pseudopregnant females and allowed to develop to term. DNA from newborn mice was evaluated by the Southern blotting technique for the presence of DNA homologous to the injected plasmid. Two of 78 mice in one series of injections showed clear homology, though the injected sequences had been rearranged. Band intensities from the two positive mice were consistent with the presence of donor DNA in most or all of the cells of the newborns. These results demonstrate that genes can be introduced into the mouse genome by direct insertion into the nuclei of early embryos. This technique affords the opportunity to study problems of gene regulation and cell differentiation in a mammalian system by application of recombinant DNA technology.”
Integration and stable germ line transmission of genes injected into mouse pronuclei.
Gordon JW, Ruddle FH.
Science. 1981 Dec 11;214(4526):1244-6.
ABSTRACT: “Genetic material has been successfully transferred into the genomes of newborn mice by injection of that material into pronuclei of fertilized eggs. Initial results indicated two patterns of processing the injected DNA: one in which the material was not integrated into the host genome, and another in which the injected genes became associated with high molecular weight DNA. These patterns are maintained through further development to adulthood. The evidence presented indicates the covalent association of injected DNA with host sequences, and transmission of such linked sequences in a Mendelian distribution to two succeeding generations of progeny.”
In summary, they injected some heterologous DNA into the pronuclei of fertilized mouse eggs. This DNA was eventually covalently associated with the host DNA (integrated) and was also successfully transmitted to the progeny of the resulting genetically-modified mice (transgenic), therefore it was inherited as a new DNA piece, a new genetic trait, thereby creating a new mouse strain, a new animal model, a trangenic mouse. Isn’t that splendid and beautifully simple? Indeed, but someone had to envisage first the experiment, someone had to carry out the injections successfully. Someone was first in demonstating this was actually possible. This was Frank Ruddle.
On behalf of the International Society for Transgenic Technologies (ISTT) I want to express my most sincere condolences to his family, colleagues and friends. This is a great loss for the transgenic community.
The recent and most successful 11th Transgenic Technology (TT2013) meeting, held in Guagnzhou (China) on 25-27 February 2013 and organized by Prof. Ming Zhao (Southern Medical University)l, on behalf of the International Society for Transgenic Technologies (ISTT), has been reported, commented and covered by pictures, videos and TV- interviews at the most popular and visited Chinese science-oriented web portal biodiscover.com. Footage includes TV-interviews to Prof. Ming Zhao, Chair of the TT2013 meeting; Prof. Xiang Gao, Director of the Model Animal Research Center of Nanjing University, Nanjing, China; Prof. Zhu-gang Wang, Director of the Shanghai Research Center for Model Organisms, Shanghai, PR China; and Dr. Lluis Montoliu, President of the ISTT, among other.
Immediately after the Chinese Spring festival, the Chinese New Year’s celebrations, the ISTT family was gently bitten by the Chinese snake. The 12th Transgenic Technology meeting, TT2013, held in Guangzhou, the capital of the province of Guandong, inaugurated the year of the snake, in the Chinese calendar. Ancient Chinese wisdom says a snake in the house is a good omen because it means that your family will not starve. People born in the Year of the Snake are keen and cunning, quite intelligent and wise. They are great mediators and good at doing business. Therefore, all the popular Chinese signs already indicated we would be enjoying a very successful and lucky TT2013 meeting. And, I’m most glad to say this was indeed the case!. The ISTT family and newcomers we all enjoyed an excellent conference where all invited speakers contributed extensively to this success, sharing their latest and most exciting results in the field of animal transgenesis and triggering interesting discussions. The quality of the talks was excellent and, noteworthy it was impressive to learn and discover how advanced and innovative to different aspects of the genetic modification of animals our Chinese colleagues are and have been progressing, thanks to a clear support from their Chinese Government and institutions. The influential Chinese science was represented at this TT2013 meeting by several top scientists in their respective field, using rodents, livestock or fish as experimental animal models, and all working in China, including: Qi Zhou, Jinsong Li, Xiang Gao, Bo Zhang, Liangzue Lai, Depei Liu, Guo-Liang Xu, Ning Li and Zhu-Gang Wang.
Ming Zhao, the Chair of the TT2013 meeting, from the host institution, the Southern Medical University of Guangzhou, worked very hard, leading a large group of local collaborators that brought the TT2013 conference to a success. The TT2013 meeting kicked off with a pre-meeting dinner, at a cruise upon the Pearl River, another majestic snake with multiple branches that crosses the city of Guangzhou at many locations. As soon as the darkness covered the city we discovered numerous impressive buildings and bridges, nicely illuminated with colorful neons, dominated by the Canton Tower, an outstanding communication tower more than 600 meters height.
The TT2013 meeting took place at the Baiyun International Convention Center (BICC) in Guangzhou, a gigantic conference center holding hotels, restaurants, seminar rooms and anything a meeting venue would require. We only occupied a small fraction of one of the five dedicated buildings of this enormous conference complex, and everything we needed, the seminar room, the exhibitor’s hall, the poster boards and the eating and drinking places were tightly and nicely grouped into one single location. Furthermore, most of TT2013 delegates were also lodged in one of the two large hotels of the BICC complex. Therefore we had everything we required handy and concentrated.
About 350 delegates gathered for the TT2013 meeting in Guangzhou, including representatives from 31 exhibiting companies that sponsored the conference and, hence, decisively contributed to its success. All sponsors must be praised for their most generous support. The conference included talks from 33 invited speakers, coming from many countries around the world, from Europe, America, Australia and Asia, thus highlighting the well-known international soul of the Society, also regularly reflected at the TT meetings. TT2013 participants were coming from as many as 27 different countries. Such phenomenal enterprise could not be managed without the devoted hard work of Ming Zhao’s large group of collaborators from the Southern Medical University, led by W. Chen, Xianyan Liu, Bibo Liang, Xiangguang Wu and all the rest of young and helpful students appointed by the chair of this conference. Their committed work must be acknowledged and commended.
In Guangzhou, at the TT2013 meeting, the 9th ISTT Prize for outstanding contributions to transgenic technologies, generously sponsored by genOway, was awarded to Allan Bradley, Director Emeritus of the Wellcome Trust Sanger Institute (WTSI), in Hinxton, UK, and leader of the Mouse Genomics Team at WTSI. Upon receiving the ISTT Prize, he delivered a great inspirational talk about his personal journey over three decades (1980-2013) on embryonic stem cells technologies he had the privilege to witness and be part of it from the first row. In awarding this ISTT prize to Allan Bradley, the ISTT Prize committee acknowledged his many fundamental contributions to the science and technology of manipulating the mouse genome. His pioneering mouse embryonic stem (ES) cell work in the 1980′s, demonstrating germ-line transmission and the great potential of ES cells to generate mice carrying mutations in endogenous genes, established milestones in a field that saw the award of the 2007 Nobel Prize in Physiology or Medicine to Capecchi, Evans, and Smithies. Later, he generated a number of broadly relevant knockout mouse models that are still used regularly today. His subsequent research has developed new methods for the genetic analysis and genetic modification of mice. These developments have been instrumental for advancing mouse genetics studies and the use of mice to understand the human genome. Furthermore, his strong vision and leadership at the Wellcome Trust Sanger Institute, which he directed from 2000-2010, was key to creating the international consortia whose aim was to systematically disrupt every gene in the mouse genome, resulting in a massive impact on the field of transgenic technologies. In Guangzhou, the sponsor of this ISTT Prize, genOway, was represented by Yacine Cherifi.
Another important award that has rapidly gained prestige and recognition among the youngest researchers and technologist in our field is the ISTT Young Investigator Award. The ISTT Young Investigator Award recognizes outstanding achievements by a young scientist who will keep the field of transgenic technologies vibrant with new ideas and who has recently received his or her advanced professional degree. The ISTT Young Investigator Award is generously sponsored by inGenious Targeting Laboratory (iTL). At the TT2013 meeting in Guangzhou, the second edition of this ISTT Young Investigator Award was received by Toru Takeo, from the Center for Animal Resources and Development, Kumamoto University, Japan. The Award committee considered that Toru Takeo’s work, in Naomi Nakagata’s laboratory, represented a major improvement of mouse sperm cyropreservation and IVF techniques, thereby greatly facilitating the archiving and sharing of many mouse models produced by the transgenic community. Toru Takeo summarized his recent achievements in mouse sperm cryopreservation and IVF with a very interesting talk where he highlighted the value and uniqueness of receiving a combined training in Pharmaceutical Sciences and Reproductive Biology, leading to his successful use of several drugs and compounds that have boosted sperm cryopreservation efficiencies in mice. In Guangzhou, the sponsor of this ISTT Young Investigator Award, inGenuious Targeting laboratory, was represented by Ailan Lu.
At the end of the TT2013 meeting, as it has become a tradition in the closing ceremonies of TT meetings, since the TT2015 meeting in Barcelona, it was the time to reveal and present the next venue for the following conference, the 12th Transgenic Technology meeting, TT2014, which will be held in Edinburgh, Scotland, UK. Bruce Whitelaw (Roslin Institute, University of Edinburgh) and Douglas Strathdee (Beatson Institute, Glasgow) represented the local Organizing Committee (the third Organizer, Peter Hohenstein, could not attend the meeting in China). Douglas Strathdee, Chair of the TT2014 conference, introduced their vision and aims for the TT2014 meeting in Edinburgh, depicting a combination of well-consolidated sessions, already classical at TT meetings, with some interesting innovative challenges, including an increased number of short oral presentations, Poster teasers and a practical workshop on zebrafish transgenic technologies. Additional information for this TT2014 meeting will be regularly available from its corresponding web site: www.tt2014.org. The Organizers have already activated an official TT2014 meeting email address to receive suggestions, inquiries, comments and any request of information related to this conference: email@example.com.
Finally, last but not least, once the TT2013 meeting was finished, immediately next, the relay was passed to Liangping Li and Wenhao Xu, who, together with Jing An and Ming Zhao, organized a practical hands-on transgenic workshop, hence fulfilling one of the most important missions of our Society, that of teaching, forming, educating scientists and technologies with the latest methods in the generation and analysis of genetically-modified animal. This practical course was chaired by Wenhao Xu and hosted by Liangping Li, at the newly refurbished and excellently equipped Disease Model Animal Center of the Sun Yat-Sen University in Guangzhou, one the biggest and most prestigious universities in China. 30 participants attended this 2013 Transgenic Workshop and were taught by a team of generous instructors from various countries in the world, including ISTT members and delegates from the sponsoring companies. A variety of microinjection techniques were discussed and performed by the participants, including DNA embryo pronuclear injection, laser-assisted injection of ES cells, piezo-assisted ICSI, non-surgical embryo transfer, colony management and assisted reproduction techniques, among other useful methods in the daily work of a modern transgenic facility.
In summary, the TT2013 meeting and 2013 Transgenic Workshop in Guangzhou, China, have been again two most successful and memorable events. On behalf of the International Society for Transgenic Technologies (ISTT), I can only express my deepest appreciation to Ming Zhao, Liangping Li, Wenhao Xu, Jing An and the rest of members of the local organizing and advisory committees for having put together such a wonderful conference and practical course, thereby maintaining and further expanding the highest standards and quality of the TT meetings series. Alison Cameron, our ISTT administrative assistant, deserves here to be greatly acknowledged for her instrumental collaboration during the preparation of this TT2013 meeting and workshop and for her helpful contribution to the success of this first visit of the ISTT family to Asia. We can conclude by stating that, yes, the ISTT family was gently bitten by the Chinese snake, and this resulted in a rewarding and unforgettable experience.
The International Society for Transgenic Technologies (ISTT) has decided, once again, to co-sponsor the IX Transgenic Animal Research Conference, hosted by the Department of Animal Science, UC Davis, and organized by ISTT Member Prof. James D. Murray. This conference will be held at the Granlibakken Conference Center, in Tahoe City, CA, USA, on 11-15 August 2013. This is a classical conference, most complementary to the TT meeting series, and specifically devoted to basic and applied projects, research and technical developments using non-rodent genetically modified animals. The ISTT is proud to have supported the two previous UC Davis Transgenic Conferences in Tahoe held in 2009 and 2011.
According to the conference web site: This is the ninth international meeting hosted by UC Davis to bring together representatives from the leading laboratories worldwide doing cutting edge work on transgenic research in non-murine animals, including livestock, fish and poultry species. The previous meetings were each attended by up to 160 participants from 12 to16 different countries throughout the globe. Each conference, in addition to reviews and papers on transgenic animals, included presentations covering technical developments in areas such as nuclear transfer-based cloning, cell transformation, vector design, and nuclease-directed gene insertion that affect the production of transgenic animals. Oral presentations are by invitation, with participants encouraged to contribute poster presentations. The upcoming conference will again focus on state-of-the-art science in the field of transgenic research. Presentations will address cutting-edge methodology, technical improvements, and current progress towards producing transgenic animals for biomedical and agricultural applications. The intent of these meetings is to bring together scientists to discuss progress, problems, and potential application of transgenic technology for animal applications. The meeting will consist of invited presentations and submitted posters. Two afternoons from noon to 4 p.m. and one evening will be free to allow for small group interactions and to take advantage of the great natural beauty and recreational activities in the Lake Tahoe area.
Already appointed and confirmed Speakers include:
- Matt Wheeler (Illinois) – opening talk
- Bruce Whitelaw (Edinburgh) – closing talk , ISTT Member
- Scott Fahrenkrug (Minnesota) – TALENS in livestock
- Emmanuelle Charpentier (Germany/Sweden) – CRISPR RNA-programming technology
- Caitlin Cooper (Davis) – feeding hLZ and hLF milk to pigs
- Hongbin He (China) – FMDV resistance
- Angelika Schnieke (Germany) – cancer models in pigs
- Chuck Long (A&M) lentiviral production of livestock
- Irina Polejaeva (Utah) – tg goat cardiovascular models
- Goetz Laible or Stefan Wagner (NZ) – KO of beta-lactoglobulin and transduction of the mammary gland
- Rob Etches (Crystal Biosciences) – heavy chain KO chickens
- Yonglun Luo (Alun) (Denmark) – adeno-assoc HR + talens / BCRA-1
- Mike McGrew (Roslin) growing and modifying avian primordial germ cells, including transposons
- Tim Doran (Aust) Virus disease resistant transgenic poultry and fish
- Derek Nimmo (UK) – TG mosquito for control of dengue fever
The International Society for Transgenic Technologies (ISTT) has agreed to co-sponsor the 7th Workshop on Innovative Mouse Models (IMM2013), which will be held at the Leiden University Medical Center (LUMC), in Leiden, The Netherlands, on 13-14 June 2013. This will be the third consecutive edition of this meeting series that is granted with the co-sponsorship of the ISTT, after the IMM2011 and the IMM2009 editions, due to its interest and relevance for the community of researchers using genetically-modified mice. The IMM2013 workshop is organized by: Jos Jonkers (NKI-AVL, Amsterdam, The Netherlands), Paul Krimpenfort (NKI-AVL, Amsterdam, The Netherlands), Werner Mueller (University of Manchester, Manchester, United Kingdom), Hein te Riele (NKI-AVL, Amsterdam, The Netherlands), Els Robanus-Maandag (LUMC, Leiden, The Netherlands), Marian van Roon (VU, Amsterdam, The Netherlands and ISTT Member) and Sjef Verbeek (LUMC, Leiden, The Netherlands and ISTT Member).
According to the IMM2013 workshop web page: The primary goal of this two-day workshop is to bring together a diverse group of scientists interested in advanced genome alteration approaches in the mouse, including key developers of emerging technologies as well as researchers who wish to apply and assess these new approaches. The IMM2013 workshop will encourage an in-depth and unvarnished discussion of these technologies and novel developments. This 2-day workshop will have a mixture of invited speakers and selected presentations. Keynote lectures will be given by:
- Anton Wutz (UK) haploid ESC
- Haoyi Wang (US) iPS / TALENs
- Bill Skarnes (UK) high throughput TALENs
- Ben Davis (UK) docking site/ new recombinases
- Yann Herault (France) Cre transgenic mice
- Kevin Brindle (UK) MRI
- Mathijs Verhagen (NL) large scale phenotyping
- B Kappes (US) TALENs
- Zoltan Ivics (Germany) Transposons
Submit your comment to FDA regarding the finding of no significant environmental impact for the transgenic salmonTuesday, January 22nd, 2013
The US Food and Drug Administration (FDA) released a document on December 26, 2012, reporting the finding of no significant environmental impact concerning a genetically engineered Atlantic salmon (AquAdvantage, produced by the company AquaBounty, Maynard, Mass., USA). According to this last report, and all the many previous studies undertaken, this transgenic fish is a safe food product and is concluded that will have no significant impact for the environment. FDA has issued this last draft environmental assessment (EA) for public comment, related to the agency’s review of an application concerning this AquAdvantage Salmon. Anyone can submit a comment to FDA on this last report. Comments will be accepted until February 25, 2013, 11:59 PM. For a review of the long administrative and review process associated with this transgenic salmon, which can be the biotechonology product derived from a genetically modified animal which might be authorised soon as food for human consumption, please visit this previous ISTT blog entry.
The International Society for Transgenic Technologies (ISTT) is pleased to announce the latest updated scientific program for the 11th Transgenic Technology (TT2013) meeting, which will be held in Guangzhou, China, on February 25-27, 2013, followed by a 3-day hands-on practical workshop on basic microinjection techniques, on February 28-March 2, 2013. The TT2013 Meeting is organized by Prof. Ming Zhao (Southern Medical University, Guangzhou) and will be held at the Guangzhou Baiyun International Convention Center. The associated hands-on workshop is organized by Dr. Wenhao Xu (University of Virginia, Charlottesville, VA, USA) in collaboration with Prof. Liangping Li (Sun Yat-sen University, Guangzhou, China), Prof. Jing An (Cancer Institute, Southern Medical University, Guangzhou, China) and Prof. Ming Zhao. The practical workshop will be held at the Sun Yat-sen University, Guangzhou. Submission of late abstracts will be still accepted until January 24, 2013. Standard Registration fees apply until January 31, 2013. Registration to attend the TT2013 meeting should be done through the TT2013 meeting web site. Please register soon to attend the 2013 Edition of this world reference conference-series on animal transgenic technology.
The updated TT2013 program includes the following confirmed invited speakers:
- Fernando Benavides (MD Anderson Cancer Center, Smithville, TX, USA)
- Allan Bradley (Wellcome Trust Sanger Institute, Hinxton/Cambridge, UK) ISTT Prize
- James Bussell (Wellcome Trust Sanger Institute, Hinxton/Cambridge, UK)
- Shannon Byers (The Jackson Laboratory, Bar Harbor, ME, USA)
- Michael Dobbie (Australian Phenomics Facility, The Australian National University, Canberra, Australia)
- Scott Fahrenkrug (Recombinetics, Minneapolis, MN, USA)
- Malcolm France (Sydney, Australia)
- Xiang Gao (Model Animal Research Center of Nanjing University, Nanjing, PR China)
- Alfonso Gutiérrez-Adán (Dep. Animal Reproduction, INIA, Madrid, Spain)
- Yann Herault (Institut Clinique de la Souris, ICS and IGBMC, Illkirch/Strasbourg, France)
- Benoît Kanzler (Max-Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany)
- Dietmar Kappes (Fox Chase Cancer Center, Philadelphia, PA, USA)
- Takashi Kohda (Department of Epigenetics, Medical Research Institute, Tokyo Medical and Dental University, Japan)
- Thomas Kolbe (Biomodels Austria and Institute for Biotechnology in Animal Production, IFA-Tulln, Austria)
- Takashi Kuramoto (Institute of Laboratory Animals, Kyoto University, Kyoto, Japan)
- Liangxue Lai (Guangzhou Institute of Biomedicine and Health, Chinese Academy of Science, Guangzhou, PR China)
- Jinsong Li (Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, PR China)
- Ning Li (State Key Laboratories for Agrobiotechnology, China Agricultural University, Beijing, PR China)
- Depei Liu (Chinese Academy of Medical Science and Peking Union Medical College, Beijing, PR China) TT2013 Opening Lecture
- Pentao Liu (Wellcome Trust Sanger Institute, Hinxton/Cambridge, UK)
- Kent Lloyd (University of California, Davis, CA, USA)
- Kyle D. Lutes (Department of Computer and Information Technology-CIT Faculty, Purdue University, West Lafayette, IN, USA)
- Shoukhrat Mitalipov (Oregon National Primate Research Center, OHSU, Beaverton, OR, USA)
- Naomi Nakagata (Center for Animal Resources and Development, Kumamoto University, Japan)
- Catheryn O’Brien (The Walter and Eliza Hall Institute, Melbourne, Australia)
- Masaru Okabe (Genome Information Research Center Research, Institute for Microbial Diseases, Osaka University, Osaka, Japan)
- Jan Parker-Thornburg (MD Anderson Cancer Center, Houston, TX, USA)
- Xin-an Pu (The Ohio State University, Comprehensive Cancer Center, Columbus, OH, USA)
- Toru Takeo (Center for Animal Resources and Development, Kumamoto University, Japan) ISTT Young Investigator Award
- Zhu-Gang Wang (Shanghai Research Center for Model Organisms, Shanghai, PR China)
- Guoliang Xu (Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, PR China)
- Bo Zhang (College of Life Sciences, Peking University, Beijing, PR China)
- Qi Zhou (The State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, PR China)