Meet the ISTT at the 8th Workshop on Innovative Mouse Models (IMM2015)

May 22nd, 2015
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Meet the ISTT at the 8th Workshop on Innovative Mouse Models (IMM2015), 11-12 June 2015, in Leiden, the Netherlands

Meet the ISTT at the 8th Workshop on Innovative Mouse Models (IMM2015), 11-12 June 2015, in Leiden, the Netherlands

Meet the ISTT at the 8th Workshop on Innovative Mouse Models (IMM2015) that will be held on 11-12 June 2015, in Leiden, the Netherlands. The popular biannual “Workshop on Innovative Mouse Models” brings together a diverse group of scientists interested in developing and exploiting mouse models to study fundamental developmental processes and to mimic human disease. Keynote speakers from leading laboratories present the latest developments on advanced genome alteration protocols, this year specifically focusing on the use of CRISPR/Cas9-assisted gene modification. Also novel imaging-technologies will be presented. The two-day workshop format combines keynote lectures and presentations of selected abstracts in order to encourage in-depth and unvarnished discussions of novel technologies.
For more information, scientific programme with confirmed speakers and registration, please visit: http://research.nki.nl/immworkshop/
Looking forward to meet many of you at IMM2015 in Leiden!

The 11th ISTT Prize jointly awarded to Jennifer Doudna and Emmanuelle Charpentier

April 18th, 2015
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The 11th ISTT Prize jointly awarded to Jennifer Doudna and Emmanuelle Charpentier

The 11th ISTT Prize will be jointly awarded to Jennifer Doudna (left) and Emmanuelle Charpentier (right) at the 13th Transgenic Technology (TT2016) meeting that will be held in Prague (Czech Republic) on 20-23 March 2016. Charpentier photo courtesy of Humboldt-Stiftung/Sven Müller.

Houston, TX, USA. 18 April 2015.

The International Society for Transgenic Technologies (ISTT, Inc.) is proud to announce that the 11th ISTT Prize will be co-awarded to Dr. Emmanuelle Charpentier and Dr. Jennifer Doudna for their collaborative work on the CRISPR-Cas9 system that is rapidly advancing the field of transgenic research. The ISTT Prize is awarded to investigators who have made outstanding contributions to the field of transgenic technologies. The awardees for the 11th ISTT Prize were chosen by the ISTT Prize Committee, which consists of the ISTT President and Vice president, the CEO of genOway (the company that generously sponsors the award), and all previous ISTT prize awardees.

The Award Committee unanimously considered that Drs. Doudna and Charpentier’s work represents a major improvement in gene editing technology and molecular biology and allows the creation of precisely gene modified animal models faster than ever. They are both prominent biochemists whose pioneering work in the field of RNA regulation and elucidating the CRISPR-Cas systems in bacteria has resulted in the development of new tools to generate specific gene knock-out and knock-in animals without the requirement for embryonic stem cell manipulation. Earlier studies by other researchers had lead to the identification of clustered regularly interspaced short palindromic repeats (CRISPR) often surprisingly matching the DNA sequence of bacterial phages. The CRISPR-Cas systems were found to provide bacteria and archaea with adaptive immunity against viruses and plasmids. Both Charpentier and Doudna had been working separately on CRISPR-associated proteins, examining how they interacted with the repetitive sequences in conferring bacterial immunity. In 2011, Charpentier identified tracrRNA as a critical component of the CRISPR-Cas9 system. In a 2012 publication, which they co-authored, they demonstrated that the Cas9 enzyme from Streptococcus pyogenes (a relatively simple CRISPR system) could be targeted to perform a double strand cut at a specific DNA site and that precise targeting could be achieved using a single-guide RNA that combined the crRNA and tracrRNA (Jinek, et al, Science, 17 August 2012, p.816). As a result of their collaborative efforts, the CRISPR-Cas9 system is fast revolutionizing the transgenic technology field as researchers apply these methods to introduce subtle genome modifications at specifically targeted loci in a wide variety of cells and cell types. Certainly, their discoveries have led to what is known now as the “CRISPR-Craze” [Science 341:833-836(2013)] and will help research and the development of human therapeutics.

Dr. Jennifer Doudna was born in 1964 in Washington DC, USA. She received her PhD in Biological Chemistry and Molecular Pharmacology from Harvard Medical School, studying with Prof. Jack Szostak. She is currently a Howard Hughes Investigator at the University of California, Berkeley in the Department of Molecular and Cell Biology and the Department of Chemistry, the Head of the Division of Biochemistry, Biophysics and Structural Biology and holds the Li Ka Shing Chancellor’s Chair in Biomedical Sciences.

Dr. Emmanuelle Charpentier was born in 1968 in Juvisy-sur-Orge in France. She received her PhD in Microbiology from the Pasteur Institute. She is currently a Guest Professor at the Laboratory for Molecular Infection Medicine Sweden (MIMS), a Nordic partnership with the European Molecular Biology Laboratory (EMBL). She has also been appointed Professor at the Hannover Medical School, and is Head of the Department “Regulation in Infection Biology” at the Helmholtz Centre for Infection Research in Braunschweig (Germany). She holds an Alexander von Humboldt Professorship.

The contributions to science made by Drs. Charpentier and Doudna have been recognized by the fact that they have received numerous honors and awards, both individually and together. Notably, as collaborators, they received the Dr. Paul Janssen Award for Biomedical Research in 2014, and the Breakthrough Prize in Life Sciences in 2014.

We are delighted that both researchers have agreed to receive the ISTT Prize, thus joining the list of previously honored scientists (in descending chronological order): Janet Rossant (2014), Allan Bradley (2013), Ralph Brinster (2011), Francis Stewart (2010), Brigid Hogan (2008), Charles Babinet (2007), Andras Nagy (2005), Qi Zhou (2004), Kenneth McCreath (2002), Teruhiko Wakayama (2001). All ISTT Prize winners are given honorary ISTT membership and a unique silver sculpture representing a mouse blastocyst created by the Hungarian artist Béla Rozsnyay. Drs. Charpentier and Doudna will receive their prize at the next 13th Transgenic Technology Meeting (TT2016) that will be held in Prague (Czech Republic) on 20-23 March 2016.

Selected References from Drs. Charpentier and Doudna’s lifetime achievements:

Dr. Charpentier
1. Deltcheva E, Chylinski K, Sharma C, Gonzales K, Chao Y, Pirzada ZA, Eckert M, Vogel J and Charpentier E. 2011. CRISPR RNA maturation by trans-encoded small RNA and host factor RNAse III. Nature 471(7340):602-607.
2. Jinek M, Chylinski K, Fonfara I, Hauer M, Doudna JA and Charpentier E. 2012. A programmable dual-RNA guided DNA endonuclease in adaptive bacterial immunity. Science 337(6096):816-821.
3. Fonfara I, Le Rhun A, Chylinski K, Makarova KS, Lécrivain AL, Bzdrenga J, Koonin EV and Charpentier E. 2014. Phylogeny of Cas9 determines functional exchangeability of dual-RNA and Cas9 among orthologous type II CRISPR-Cas systems. Nucleic Acids Res. 42(4):2577-2590.

Dr. Doudna
1. Jinek M, East A, Cheng A, Lin S, Ma E and Doudna JA. 2013. RNA-programmed genome editing in human cells. eLIFE; 2:e00471. DOI: 10.7554/eLife.00471/
2. Sternberg SH, Redding S, Jinek M, Greene EC, Doudna JA. 2014. DNA interrogation by the CRISPR RNA-guided endonuclease Cas9. Nature 507:62-67.
3. Jinek M, Chylinski K, Fonfara I, Hauer M, Doudna JA and Charpentier E. 2012. A programmable dual-RNA guided DNA endonuclease in adaptive bacterial immunity. Science 337(6096):816-821.

This 11th ISTT Prize press release can be downloaded from here.

ISTT Awarded Scientists

February 27th, 2015
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ISTT Awarded Scientists (2001-2014). Outstanding researchers in the field of Transgenic Technologies that have been awarded the ISTT Prize or the ISTT Young Investigator Award

ISTT Awarded Scientists (2001-2014). Outstanding researchers in the field of Transgenic Technologies that have been awarded the ISTT Prize or the ISTT Young Investigator Award

The International Society for Transgenic Technologies (ISTT) has updated its web site and now includes, in its public pages, additional information for all the awarded scientists, outstanding researchers in the field of Transgenic Technologies, which have been awarded the ISTT Prize, generously sponsored by genOway, or the ISTT Young Investigador Award, generously sponsored by ingenious targeting laboratory.

These are the 10 outstanding scientists awarded the ISTT Prize for the period 2001-2014. The ISTT was founded in 2006 and the first ISTT Prize was awarded in Toronto, at the TT2008 meeting. Previously, these awards were known as the genOway Prize for transgenic technologies.

  • Janet Rossant, 10th ISTT Prize, TT2014 meeting, Edinburgh, UK
  • Allan Bradley, 9th ISTT Prize, TT2013 meeting, Guangzhou, China
  • Ralph L. Brinster, 8th ISTT Prize, TT2011 meeting, Florida, USA
  • A. Francis Stewart, 7th ISTT Prize, TT2010 meeting, Berlin, Germany
  • Brigid Hogan, 6th ISTT Prize, TT2008 meeting, Toronto, Canada
  • Charles Babinet, 5th genOway Prize, TT2007 meeting, Brisbane, Australia
  • Andras Nagy, 4th genOway Prize, TT2005 meeting, Barcelona, Spain
  • Qi Zhou, 3th genOway Prize, TT2004 meeting, Uppsala, Sweden
  • Kenneth J. McCreath, 2nd genOway Prize, TT2002 meeting, Munich, Germany
  • Teruhiko Wakayama, 1st genOway Prize, TT2001 meeting, Stockholm, Sweden

These are the 3 outstanding researchers awarded the ISTT Young Investigator Award for the period 2011-2014

  • Feng Zhang, 3rd ISTT Young Investigator Award, TT2014 meeting, Edinburgh, UK
  • Toru Takeo, 2nd ISTT Young Investigator Award, TT2013 meeting, Guangzhou, China
  • Xiao-Yang Zhao, 1st ISTT Young Investigator Award, TT2011 meeting, Florida, USA

Advances in the Generation of Genetically Modified Animal Models: International Course & Symposium, Institut Pasteur de Montevideo (Uruguay), 7-18 September 2015

January 21st, 2015
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Advances in the Generation of Genetically Modified Animal Models: International Course & Symposium, Institut Pasteur de Montevideo (Uruguay), 7-18 September 2015

Advances in the Generation of Genetically Modified Animal Models: International Course & Symposium, Institut Pasteur de Montevideo (Uruguay), 7-18 September 2015

The International Society for Trangenic Technologies (ISTT) proudly co-sponsors the International Course & Symposium on Advances in the Generation of Genetically Modified Animal Models, to be held at the Institut Pasteur de Montevideo (Uruguay), organized by ISTT Members Martina Crispo (Unidad de Animales Transgénicos y Experimentación, UATE, Institut Pasteur de Montevideo) and Alejo Menchaca (Instituto de Reproducción Animal de Uruguay, IRAUy), on 8-15 September 2015.

The aim is to offer a training course of excellence for researchers and technicians working in animal transgenic field. The topics will be focused on both the basic knowledge and the latest advances in transgenic technologies. The course consists of a 1st week of lectures sessions and a 2nd week of practical sessions. In addition, a mini symposium (11-12 September) is organized in order to extend the impact of the presence of the professors to other researchers, technicians and posgraduate students. Current programs for the COURSE and MINI-SYMPOSIUM.

Confirmed speakers attending this Course and mini-Symposium include:

  • Michel Cohen-Tannoudji, IPParis, France
  • Francina Langa, IP Paris, France, ISTT member
  • Ignacio Anegón, INSERM, Nantes, France, ISTT member
  • Lluis Montoliu, CNB, Spain, ISTT member
  • Jorge Sztein, consultant, Spain
  • Sylva Haralambous, HPI, Greece, ISTT member
  • Naomi Nakagata, CARD, Kumamoto U, Japan, ISTT member
  • Charles Long, Texas A&M University, USA
  • Daniel Salamone, Fagro, UBA, Argentina
  • Adrian Mutto, UNSM, Argentina
  • Marcelo Rubinstein, INGEBI, Argentina, ISTT member
  • Marcelo Bertolini, UNIFOR, Brazil

Local professors and instructors include:

  • Magdalena Cárdenas, IP Montevideo, Uruguay
  • Ana Paula Mulet, IP Montevideo, Uruguay
  • Geraldine Schlapp, IP Montevideo, Uruguay, ISTT member
  • María Noel Meikle, IP Montevideo, Uruguay, ISTT member
  • Gabriel Fernández, IP Montevideo, Uruguay
  • Ana Paula Arévalo, IP Montevideo, Uruguay
  • Martina Crispo, IP Montevideo, Uruguay, ISTT member
  • Pedro C. dos Santos, IRAUy, Uruguay
  • Natalibeth Barrera, IRAUy, Uruguay
  • Federico Cuadro, IRAUy, Uruguay
  • Alejo Menchaca, IRAUy, Montevideo, Uruguay, ISTT member

People interested in participating in this COURSE must send the COURSE Application Form to tgcourse2015@pasteur.edu.uy
A maximum of 20 students will be accepted for the COURSE taking into account personal qualifications.
There is no registration fee for the COURSE. Support for accommodation, per diem and local transportation will be provided to all participants from abroad. Travel expenses are not included.
People interested in participating in the MINI SYMPOSIUM must send the SYMPOSIUM Registration Form to tgcourse2015@pasteur.edu.uy
SYMPOSIUM fee is U$S 100.

SAVE THE DATES!
Deadline for COURSE applications is June 28th
Deadline for SYMPOSIUM registrations is July 19th
For any further information contact: tgcourse2015@pasteur.edu.uy
www.pasteur.edu.uy/index.php/en/futurecourses

 

SALAAM kick-off meeting in Munich: thinking big (the important role of large animal models)

January 19th, 2015
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SALAAM kick-off meeting in Munich: 15-17 December 2014

SALAAM kick-off meeting in Munich: 15-17 December 2014

About a month ago, shortly before the season break, and very timely to enjoy its Christmas Market (Weihnachtsmarkt), the kick-off meeting of the Project SALAAM (Sharing Advances on Large Animal Models) took place in Munich (Germany), 15-17 December 2014, beautifully organized by Eckhard Wolf and Pascale Chavatte-Palmer, Chair and Co-Chair of this EU-COST Action BM1308. This conference, open to any interested researcher in the field, represented the official launch of the SALAAM project, to discuss about the role of large animal models in Translational Medicine, “Bridging the Gap between Basic and Clinical Research”, as indicated in the SALAAM logo. During these three days, about 120 scientists, including researchers not initially associated with SALAAM (including several ISTT members), gathered at the Gene Center, LMU Munich, to share their views about the role of large animal models in biomedicine.

The meeting started with a welcome address by Eckhard Wolf (LMU, Munich, Chair of SALAAM) who set the stage and underlined the need to use appropriate animal models for succeeding in translational research. In the past, large amount of resources have been devoted to rodents, mostly mice, in biomedicine, where mouse models have become instrumental for the current understanding of how most of our genes work and greatly facilitated the progress in the post-genomic era. However, in spite of mice being widely used in Biomedicine to model human diseases, often mice fail to accurately reproduce the features associated with a given human pathology. Therefore there is an urgent need to develop non-rodent animal models that would mimic aspects of human anatomy and human physiology more closely. Pigs, small ruminants and rabbits appear to be excellent candidates to follow up the preliminary discoveries made in mice, and they are the main purpose of the SALAAM initiative, through all the appointed participants, experts in these large animal models. The conference continued for its first day with lectures by A. Aartsma-Rus (NL), and S. Wildhirt (DE), who described examples of use of large animal models for Duchenne muscular dystrophy and for the development of medical devices, respectively. The initial Ethical perspective on the use of large animals was provided by N. Stingelin (CH). This first day concluded with an interesting key-note lecture by M.M. Mohiuddin (USA) on the recent advances in pig-to-primate cardiac xenotransplantation.

On the second day, the conference presented the very large repertoire of methods and techniques that are currently available for Genetic Tailoring of large animal models. Angelika Schnieke (DE) introduced the state of art for the current genetic engineering of large animals, nicely summarizing many years of techniques and developments that have been successfully applied for the production of large genetically modified animal models. This initial talk was followed by a presentation by Lluis Montoliu (ES) on the use of CRISPR-Cas9 approaches to functionally analyze the role of non-coding genomic sequences, illustrated with some examples tested in mice, depicting the important role of rodents in proof-of-concept type of experiments, before undertaking subsequent experiments in larger animal models. B. Grzeskowiak (PL) presented an innovative set of nanomagnetic gene delivery vectors for transgenesis. Two additional talks illustrated the power of genetic engineering of the pig genome, using transposons (W.A. Kues, DE) or very elaborated gene cassettes for regulating and tracing disease genes (J.E. Jakobsen, DK). The session ended with a presentation from goats, where L. Boulanger (FR) reported the role of FOXL2 as a female sex-determining gene.

The SALAAM conference continued with a session devoted to systematic phenotyping initiatives of large animal models. At first, H. Fuchs (DE), presented the experience and phenotyping pipeline of the German Mouse Clinic, operating within the Infrafrontier consortium, and a good example of successful systematic phenotyping in mice. Next, Pascale Chavatte-Palmer (FR) discussed the achievements and challenges of imaging techniques in large animal models, through her studies on reproduction and fetal development. J. Tibau (ES) presented his interesting studies using pigs to analyze human obesity and to validate the effect of diets on the evolution of fat deposition using tomography approaches. A. Blutke (DE) introduced the impressive Munich MIDY-PIG Biobank initiative, as a unique resource for translational diabetes research. The two last talks presented the use of pigs as models for respiratory infections (K. Skovgaard, DK) or cystic fibrosis (I. Caballero, FR).

The last standard session of this SALAAM conference was devoted to discuss how to select the best animal model. This session began with an interesting presentation by J. Langermans (NL), who shared their initiative of non-human primate biobanking for translational medicine, a collaborative consortium where most of the nonhuman primate research centres in Europe were represented. He also discussed the unique features of non-human primates to investigate devastating diseases affecting us, such as the new infections (i.e. Ebola) or neurodegenerative diseases (i.e. Alzheimer, Parkinson) , often very challenging to be reproduced in non-primate animal models. Next, Antonio Gonzalez-Bulnes (ES) discussed the advantages and challenges of using pigs and sheep animal models, whereas L. Hiripi (HU) presented the unique features of the rabbit models.  V. Huygelen (BE) discussed the use of piglets to investigate the human low birth weight cases , and A. Navarrete Santos (DE) further presented rabbits as ideal models for investigating diabetes during pregnancy. Diabetes research was also the focus of the last speaker of the session, G. Pennarossa (IT), whose experimental dessigns are focused on the use of dogs to explore cell therapy-based treatments.

The SALAAM first public conference ended with an excellent and very motivating talk by Karin Blumer (CH) on the ethical aspects of using large animals. She challenged the audience with the question whether “size did matter?” when it comes to Ethics and Animal Models. Her presentation nicely illustrated the different Ethical perspectives existing in the field and, most importantly, the relevant parameters that should be taken into account in order to properly address this question. She presented the “size” of an animal as an accidental attribute, not an intrinsic value, that must not determine its moral status. This presentation triggered an interesting and live discussion among the participants.

On the third and last day, the different working groups of SALAAM gathered first independently to discuss the next initiatives and eventually shared their conclusions in a combined general session. The planned initiatives will include the organization of practical workshops on CRISPR-Cas9 and transposon technologies, the generation of specific pig Cre-transgenic lines for the production of conditional pig mutant animal models,  the need to standardize phenotyping protocols associated with additional specific training courses, the preparation of biobanks and associated databases for archiving and sharing tissues from large animal models, and the creation of a group to analyze the implementation of the 2010/63/EU Directive across Europe, the public perception and ethical issues of animal research, and the need for training to adequately communicate results to the public.

Information about future plans, initiatives and activities of the SALAAM EU-COST action will be available from its dedicated web site.

The ISTT Calendar for year 2015

January 5th, 2015
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Download a free copy of the 2015 ISTT Calendar

Download a free copy of the 2015 ISTT Calendar

Happy New Year to all ISTT Members!. Here, you can download a free copy of the 2015 ISTT Calendar. This edition has been nicely prepared by ISTT Board Member Karen Brennan (Sydney, Australia), using numerous beautiful images generously provided by members and supporting companies. Download it, print it and use it!. Enjoy it!.

Happy New Year: the ISTT finishes 2014 with 736 members

January 1st, 2015
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Happy New Year: the ISTT finishes 2014 with 736 members

Happy New Year: the ISTT finishes 2014 with 736 members

On behalf of the ISTT, I wish everyone a Happy and Prosperous New Year!

The International Society for Transgenic Technologies (ISTT) finishes year 2014 with 736 members. At the ISTT we have launched the 2015 renewal campaign and we hope that those of you that are not yet ISTT members would seriously consider registering in 2015. All information regarding renewals and new registrations is available at the JOIN-RENEW web page.

During 2015, the ISTT will co-sponsor two transgenic meetings, one in Nantes, France, and another in Montevideo, Uruguay.  Please check out these meetings using the links on the ISTT webpage, and note that by joining the ISTT, you can receive reduced registration fees or preferred registration for these meetings, among many other benefits.

With our best wishes for 2015,

Jan Parker-Thornburg, ISTT President

TT2014 meeting report published in Transgenic Research

December 28th, 2014
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TT2014 meeting report published in Transgenic Research

TT2014 meeting report published in Transgenic Research

The meeting report of the 12th Transgenic Technology meeting (TT2014), held in Edinburgh on October 6-8, 2014, and organized by Douglas Strathdee, Peter Hohenstein and Bruce Whitelaw, has just been published in the scientific journal Transgenic Research.

TT2014 meeting report on the 12th Transgenic Technology meeting in Edinburgh: new era of transgenic technologies with programmable nucleases in the foreground.
Beck IM, Sedlacek R.
Transgenic Res. 2015 Feb;24(1):179-83.

The TT2014 meeting report has been written by Inken Beck and Radislav Sedlacek (Czech Centre for Phenogenomics, Institute of Molecular Genetics, Prague, Czech Republic), who will be responsible to organize the next (13th) Transgenic Technology meeting (TT2016) in Prague on March 20-23, 2016.

New book published: Genetics of the Mouse (Springer, 2015)

December 14th, 2014
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New book published: Genetics of the Mouse. Editors: JL Guénet, F Benavides, JJ Panthier and X Montagutelli (Springer 2015)

New book published: Genetics of the Mouse. Editors: JL Guénet, F Benavides, JJ Panthier and X Montagutelli (Springer 2015)

A new book has been published in the field of mouse genetics, filling a gap created since the mid nineties, when the last similar books had been published (i.e. Lee Silver, 1995), devoted to this topic. This new book, entitled “Genetics of the Mouse” has been edited by four experiencied mouse geneticists: Jean-Louis Guénet, Fernando Benavides, Jean-Jacques Panthier and Xavier Montagutelli, and has been published by Springer (2015). The authors are all related with Institut Pasteur, in Paris, France, where Jean-Louis Guénet worked many years (currently retired), where Fernando Benavides (ISTT member and at MD Anderson Cancer Center, Smithville, TX, USA) had also worked, under the supervision of Jean-Louis Guénet, and where Jean-Jacques Panthier and Xavier Montagutelli have currently their laboratories. Jean-Louis Guénet and Fernando Benavides had also co-authored a previous text on a similar subject (Genetics of Rodents), in Spanish, published in 2003 and freely available from the ISTT web page since 2011.

This new book contains 10 chapters, as follows:

  1. Origins of the Laboratory Mouse
  2. Basic Concepts of Reproductive Biology and Genetics
  3. Cytogenetics
  4. Gene Mapping

  5. The Mouse Genome
  6. Epigenetic Control of Genome Expression
  7. Mutations and Experimental Mutagenesis

  8. Transgenesis and Genome Manipulations
  9.  The Different Categories of Genetically Standardized

  10. Quantitative Traits and Quantitative Genetics

As indicated in the Springer’s book web page: ‘This book, written by experienced geneticists, covers topics ranging from the natural history of the mouse species, its handling and reproduction in the laboratory, and its classical genetics and cytogenetics, to modern issues including the analysis of the transcriptome, the parental imprinting and X-chromosome inactivation. The strategies for creating all sorts of mutations, either by genetic engineering or by using mutagens, are also reviewed and discussed in detail. Finally, a last chapter outlines the methodology used for the analysis of complex or quantitative traits. The authors also discuss the importance of accurate phenotyping, which is now performed in the mouse clinics established worldwide and identify the limits of the mouse model, which under certain circumstances can fail to present the phenotype expected from the cognate condition in the human model. For each chapter an up-to-date list of pertinent references is provided. In short, this book offers an essential resource for all scientists who use or plan to use mice in their research.

This book is available from Springer and from Amazon

ISTT statement on animal transport

December 12th, 2014
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ISTT statement on animal transport

ISTT statement on animal transport

The International Society for Transgenic Technologies (ISTT) is committed to biomedical research that improves the health and well-being of people and animals worldwide. Transgenic technology has widely been recognized as a powerful tool for analysis of in vivo gene function and generation of animal models that are vital to the effort to develop treatments and cures for disease.

The availability of these research models for study by researchers is critically dependent on their transport between laboratories and research institutions around the world, because scientific research is a global endeavor. The wide availability of these models also precludes having to regenerate the same model as researchers can often use a model that has already been made. This practice greatly reduces the numbers of animals used for research, thus fulfilling a core ethical responsibility of researchers. Inappropriate or unavailable animal transport would directly hamper the efforts of international collaborative networks or initiatives aimed at the efficient design, generation and distribution such gene modified animal models.

Animals used in scientific research are, in the vast majority of cases, bred for this purpose. Their care and use is constantly subject to rigorous oversight to ensure that animals are used only when absolutely needed, are housed in the best available conditions and are not subject to unnecessary pain. Shipment of live animals is also undertaken with the same regard for animal care and wellbeing and in compliance with international standards for packing and handling.

The ISTT therefore supports all actions that maintain the availability of safe, humane, and regulated transport of research animals by professional carriers in compliance with international legislation, and we renounce any misguided attempts to curtail or prevent this vital practice that is absolutely necessary for our ability to develop life-saving cures.

Jan Parker-Thornburg, President
ISTT
On behalf of the ISTT Board of Directors
December 8, 2014


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